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Janet Guthmiller, DDS, PhD

Dean, Adams School of Dentistry

Dr. Claude A. Adams Jr. Distinguished Professor
Portrait of janet guthmiller

Education

  • PhD, 1993, University of Texas Health Science Center at San Antonio
  • Certificate, 1992, Periodontology, University of Texas Health Science Center at San Antonio
  • DDS, University of Iowa, 1988
  • BA, Northwestern College, 1984, Natural Science
  • AA, University of South Dakota, 1983, Dental Hygiene

Biosketch

Janet Guthmiller, DDS, PhD, became the 9th dean of the University of North Carolina Adams School of Dentistry on October 15, 2022.  Dr. Guthmiller also holds the Claude A. Adams Jr. Distinguished Professorship. She joined the UNC Adams School of Dentistry following an eight-year tenure as the dean at the University of Nebraska Medical Center College of Dentistry where she lead dental programs serving over 300 students on five campuses across 500 miles. Under her leadership, the College of Dentistry launched two new educational programs to meet the needs of today’s students and built and renovated numerous facilities to foster cutting-edge teaching and learning and delivery of patient care. A strong advocate for public service, Dr. Guthmiller served as the principal investigator on a $4 million contract from the State of Nebraska to increase oral health services to underserved citizens of Nebraska and encouraged graduates to practice in underserved rural areas. 

Dr. Guthmiller is a nationally recognized leader in dental education and an accomplished researcher, author and teacher. She has been the recipient of collegiate, university and national teaching and mentoring awards, including the Faculty Mentor of the Year from the National Student Research Group of the American Association for Dental Research in 2007 and a Chair of the American Dental Education Assocation (ADEA) Board of Directors Citation for significant contributions to dental education and ADEA through service on the New Thinking for the New Century Committee. Guthmiller’s NIDCR funded research has encompassed molecular biological studies of periodontal pathogens and expression and function of innate antimicrobials. She has published numerous manuscripts and abstracts, a book and several book chapters. Dr. Guthmiller is a diplomate of the American Board of Periodontology and fellow of the American College of Dentists and the International College of Dentists.

Dr. Guthmiller is active in many professional organizations.  She is past chair of the administrative board of the ADEA Council of Deans and past-president of the Supreme Chapter of Omicron Kappa Upsilon, a national dental honor society. She is the recipient of the Distinguished Alumni Award for Professional Achievement from Northwestern College, the Distinguished Alumnus Award from the Cellular and Structural Biology program at the University of Texas Health Science Center in San Antonio and an Honorary Life Membership Award (2016) and Distinguished Service Award in 2021 from the UNMC College of Dentistry Alumni Association. 

Dr. Guthmiller previously served as associate dean for academic affairs and professor of periodontology at UNC, overseeing all dental educational programs, faculty development and student admissions and affairs from 2007-2014. Prior to that, she served on the faculty at the University of Maryland School of Dentistry and the University of Iowa College of Dentistry. She earned an associate degree in dental hygiene from the University of South Dakota, a bachelor’s from Northwestern College, a DDS from the University of Iowa College of Dentistry and a periodontal certificate and a doctorate in cellular and structural biology from the University of Texas Health Science Center at San Antonio as a part of the NIH-sponsored Dentist-Scientist Program.

Honors and Awards

Awarded by the University of Nebraska Medical Center College of Dentistry Alumni Association, for advancing the mission of the college through educational programming, securing funding, renovations and student’s patient care experiences and for leadership of the College through the pandemic.

Nominated to the U.S. Secretary of Defense’s Joint Civilian Orientation Program

Awarded by University of Nebraska Medical Center College of Dentistry Alumni Association

Publications

Books:

Brogden KA, Guthmiller JM, eds. Polymicrobial Diseases. ASM Press, Washington, DC: 2002. 427 pages.

Brogden KA, Guthmiller JM, eds. Polymicrobial Diseases. Chinese translation: Tianjin Science and Technology Press: 2006.

Book Chapters:

  1. Guthmiller, JM. Moving out to move up. Viera AJ, Kamer, R. Management and leadership skills for medical faculty and Healthcare Executives – A Practical Handbook. Springer Publishing, New York: 2020. Pages 265-273.
  2. Meyer, KM., Guthmiller, JM. Managing Managers. Management and leadership skills for medical faculty and Healthcare Executives – A Practical Handbook. Springer Publishing, New York: 2020. Pages 111-120.
  3. Guthmiller, JM. Moving out to move up. Viera AJ, Kamer, R. Management and leadership skills for medical faculty – A Practical Handbook. Springer Publishing, New York: 2016. Pages 249-257.
  4. Guthmiller JM, Joly S. Effect of defensins on susceptibility to infection at the mucosal surface. Virulence mechanisms of bacterial pathogens. Brogden KA, Minion FC, Cornick N, Stanton, TB, Zhang Q, Nolan LK, Wannemuehler MJ. Virulence Mechanisms of Bacterial Pathogens. 4th ed. ASM Press, Washington, DC: 2007. Pages 265-280.
  5. Guthmiller JM. Local delivery of antimicrobial agents in the treatment of periodontitis. Wilson TG, Kornman KS. Fundamentals of Periodontics. 2nd ed. Quintessence Publishing Co., Inc. Chicago, IL: 2003. Pages 416-429.
  6. Guthmiller JM, Novak KF. Periodontal Diseases. Brogden KA, Guthmiller JM.

Polymicrobial Diseases. ASM Press, Washington, DC: 2002. Pages 137-152.

  • Brogden KA, Guthmiller JM. Polymicrobial Diseases: Current and future research. Brogden KA, Guthmiller JM. Polymicrobial Diseases. ASM Press, Washington, DC: 2002. Pages 403-410.

Dissertation:

Guthmiller JM. Elucidating a role for Actinobacillus actinomycetemcomitans in periodontal disease. Publication No. 94-22001. The University of Texas Graduate School of Biomedical Sciences at San Antonio, San Antonio, TX: 1993. Pages i-158.

Journal Articles/On-line educational modules (All Refereed):

  1. Fischer, C.L., Bates, A.M., Lanzel, E.A., Guthmiller, J.M., Johnson, G.K., Singh, N.K.,

Kumar, A., Vidva, R., Abbasi, T., Vali, S., Xie, X.J., Zeng, E., Brogden, K.A. Computational models accurately predict multi-cell biomarker profiles in inflammation and cancer. Sci Rep. 2019 Jul: 26 9(1): 10877.doi:10.1038/s41598-019047381-4.

  • Abhyankar, V. P., Bates, A. M., Fischer, C. L., Johnson, G. K., Guthmiller, J. M., Progulske-Fox, A., and Brogden, K. A. Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B. Data Brief. 2018 Dec 31;22: 964-970. doi: 10.1016/j.dib.2018.12.087. eCollection 2019 Feb.
  • Bates, A. M., Fischer, C. L., Abhyankar, V., Johnson, G. K., Guthmiller, J. M., Progulske- Fox, A., and Brogden, K. A. Matrix metalloproteinase response of dendritic cell, gingival epithelial keratinocyte, and T-cell transwell co-cultures treated with Porphyromonas gingivalis hemagglutinin-B. Int J Mol Sci. 2018 Dec 7;19(12). pii: E3923. doi: 10.3390/ijms19123923.
  • Garaicoa, JL, Fischer, CL, Bates, AM, Holloway, J, Avila-Ortiz, G, Guthmiller, JM, Johnson, GK, Stanford, C, Brogden, KA. Promise of combining antifungal agents in denture adhesives to fight Candida species infections. J Prosthodont. 2018 Oct;27(8):755- 762. doi: 10.1111/jopr.12565. Epub 2016 Nov 21.
  • Lanzel, EA, Gomez Hernandez, PM, Bates, AM, Treinen, CN, Starman, EE, Fischer, CL, Parashar, D, Guthmiller, JM, Johnson GK, Abbasi T, Vali, S, Brogden, KA. Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models. Cancer Immunol Immunother. 2016; 65(12):1511-1522.
  • Mehalick, LA, Poulsen, C, Fischer, CL, Lanzel, EA, Bates, AM, Walters, KS, Cavanaugh, JE, Guthmiller, JM, Johnson, GK, Wertz, PW, and Brogden, KA. Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells. Data in Brief. 2015; 5:285-291.
  • Ricker, K., Mihas, P, Lee, JY, Guthmiller, JM, Roberts, MW, Divaris, K. Educators’ and Applicants’ View of the Postdoctoral Pediatric Dentistry Admission Process: A Qualitative Study. J Dent Edu. 2015; 79(11): 1272-1278.
  • Poulsen, C., Mehalick, LA, Fischer, CL, Lanzel, E A, Bates, AM, Walters, KS, Cavanaugh, JE, Guthmiller, JM, Johnson, GK, Wertz, PW, and Brogden, KA. Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells. Toxicol Lett. 2015; 19:237 (1)21-29.
  • Leelakanok, N, Fischer, CL, Bates, AM, Guthmiller, JM, Johnson, GK, Salem, AK, Brogden, KA, Brogden, NK. Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial kearatinocytes in cell culture conditions. Toxicol Lett. 2015; 239(2):90-96.
  • Byrd, G. Quinonez, RB. Offenbacher, S. Keels, MA, Guthmiller JM. Coordinated pediatric and periodontal care of a child with Down Syndrome. Pediatr Dent. 2015; 37 (4) 381-385.
  • Wilder, RS and Guthmiller JM. Empowerment through Mentorship and Leadership. J Evid Based Dent Pract. 2014; 14 Supp:222-226.
  • Wehmeyer M, Corwin CL, Guthmiller JM, Lee JY. The impact of oral health literacy on periodontal health status. J Public Health Dent. 2014; 74 (1) 80-87.
  • Kohlgraf K, Ackermann A, Burnell K, Srikantha R, Joly S, Bartlett J, Gakhar L, Johnson G, McCray P Jr, Guthmiller JM, Brogden K. Quantitation of SPLUNC1 in saliva with an xMAP particle-based antibody capture and detection immunoassay. Arch Oral Biol 2012; 57:197-204.
  • Guthmiller JM. Section Author – Gingival Diseases – on-line educational module. Published online (11-11-11): http://adea.cdesource.com/resource_center.
  • Tymkiw KD, Thunell DH, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM. Influence of smoking on gingival crevicular fluid cytokines in severe chronic periodontitis. J Clin Periodontol 2011; 38:219-228.
  • Johnson GK, Guthmiller JM, Joly S, Organ CC, Dawson DV. Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures. J Periodont Res 2010; 45:583-588.
  • Thunell DH, Tymkiw KD, Johnson GK, Joly S, Burnell KK, Cavanaugh JE, Brogden KA, Guthmiller JM. A multiplex immunoassay demonstrated reductions in gingival crevicular fluid cytokines following initial periodontal therapy. J Periodont Res 2010; 45:148-152.
  • Joly S, Compton LM, Pujol C, Kurago ZB, Guthmiller JM. Loss of human β-defensin 1, 2, and 3 expression in oral squamous cell carcinoma. Oral Microbiol Immunol 2009; 24:353-360.
  1. Wilder RS, Iacopino A, Feldman C, Guthmiller JM, Linfante J, Lavigne S, Paquette D. Periodontal-systemic disease education in United States and Canadian dental schools. J Dent Educ 2009; 73:38-52.
  2. Franzman MR, Burnell KK, Dehkordi-Vakil FH, Guthmiller JM, Dawson DV, Brogden KA. Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture. Int J Antimicrob Agents 2008; 33:14-20.
  3. Pingel LC, Kohlgraf KG, Hansen CJ, Eastman CG, Dietrich DE, Burnell KK, Srikantha RN, Xiao X, Belanger M, Progulske-Fox A, Cavanaugh JE, Guthmiller JM, Johnson GK, Joly S, Kurago ZB, Dawson DV, Brogden KA. Human β-defensin 3 binds to hemagglutinin b (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response. Immunol Cell Biol 2008; 86:643-649.
  4. Weistroffer P, Joly S, Srikantha T, Brogden KA, Tack BF, Guthmiller JM. SMAP29 congeners demonstrate activity against oral bacteria and reduced toxicity against oral keratinocytes. Oral Microbiol Immunol 2008; 2:89-95.
  5. Statz TA, Guthmiller JM, Humbert LA, Johnson GK. Intravenous bisphosphonate- associated osteonecrosis of the jaw. J Periodontology 2007; 28:2203-2208.
  6. Johnson GE, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000 2007; 44:178-194.
  7. al Habashneh R, Guthmiller JM, Levy S, Johnson GK, Dawson DV, Fang Q. Factors related to utilization of dental services during pregnancy. J Clin Periodontol 2005; 32:815- 821.
  8. Brogden KA, Guthmiller JM, Salzet M, Zasloff M. The nervous system and innate immunity: the neuropeptide connection. Nature Immunology 2005; 6:558-564.
  9. Joly S, Organ CC, Johnson GK, McCray PB Jr, Guthmiller JM. Correlation between β-defensin expression and induction profiles in gingival keratinocytes. Mol Immunol 2005; 42:1073-1084.
  • Brogden KA, Guthmiller JM, Taylor CE. Human polymicrobial infections. Lancet 2005; 365:253-255.
  • Joly S, Maze CM, McCray PB Jr, Guthmiller JM. Human β-defensins demonstrate strain- selective activity against oral microorganisms. J Clin Micro 2004; 42:1024-1029.
  • Bissell J, Joly S, Johnson GK, Qian F, Dawson D, McCray PB Jr, Guthmiller JM. Expression of β-defensins in gingival health and in periodontal Disease. J Oral Path Med 2004; 33:278-285.
  • Premratanachai P, Joly S, Johnson GK, McCray PG Jr, Jia HP, Guthmiller JM. Expression and regulation of novel human β-defensins in gingival keratinocytes. Oral Microbiol Immunol 2004; 19:111-117.
  • Brogden K A, Heidari M, Sacco RE, Palmquist D, Guthmiller JM, Johnson G K, Jia HP, Tack BF, McCray PB Jr. Defensin induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiol Immunol 2003; 18(2):95-99.
  • Clark-Holke D, Drake D, Walton R, Rivera E, Guthmiller JM. Bacterial penetration through canals of endodontically treated teeth in the presence or absence of the smear layer. J Dentistry 2003; 31:275-281.
  • Brogden KA, Guthmiller JM. Polymicrobial diseases, a concept whose time has come. ASM News 2003; 69(2):69-73.
  • Guthmiller JM, Vargas KG, Srikantha R, Schomberg LL, Weistroffer PL, McCray PB Jr, Tack BF. Susceptibility of oral bacteria and yeast to mammalian cathelicidins. Antimicrob Agents Chemother 2001; 45:3216-3219.
  • Guthmiller JM, Hassebroek-Johnson JR, Weenig DR, Johnson GK, Kirchner HL, Kohout, FK, Hunter SK. Periodontal disease in pregnancy complicated by type 1 diabetes mellitus. J Periodontology 2001; 72:1485-1490.
  • Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PG Jr. Discovery of new human β-defensins using a genomics-based approach. Gene 2001; 263(1-2):211-218.
  • Alpha CX, Guthmiller JM, Cummings HE, Schomberg LL, Noorani SM. Molecular analysis of Peptostreptococcus micros isolates from periodontally involved patients. J Periodontology 2001; 72:877-882.
  • Guthmiller JM, Lally ET, Korostoff J. Beyond the specific plaque hypothesis: Are highly leukotoxic strains of Actinobacillus actinomycetemcomitans a paradigm for periodontal pathogenesis. Critical Reviews in Oral Biology and Medicine 2001; 12(2):116-124.
  • Mathews M, Jia HP, Guthmiller JM, Losh G, Graham S, Johnson GK, Tack BF, McCray PB Jr. Production of β-defensin antimicrobial peptides by oral mucosa and salivary glands. Infect Immun 1999; 67:2740-2745.
  • Turng BF, Guthmiller JM, Minah GE, Falkler WA Jr. Development and evaluation of a selective and differential medium for the primary isolation of Peptostreptococcus micros. Oral Microbiol and Immunol 1996; 5:356-361.
  • Guthmiller JM, Kolodrubetz D, Kraig E. Mutational analysis of the putative leukotoxin transport genes in Actinobacillus actinomycetemcomitans. Microbial Pathogenesis 1995; 18:307-321.
  • Guthmiller JM, Kolodrubetz D, Kraig E. A panel of probes detects DNA polymorphisms in human and non-human primate isolates of a periodontal pathogen, Actinobacillus actinomycetemcomitans. Microbial Pathogenesis 1993; 14:103-115.
  • Guthmiller JM, Kraig E, Cagle MP, Kolodrubetz D. Sequence of the lktD gene from Actinobacillus actinomycetemcomitans. Nucleic Acids Res 1990; 18:5292.
  • Guthmiller JM, Kolodrubetz D, Cagle MP, Kraig E. Sequence of the lktB gene from Actinobacillus actinomycetemcomitans. Nucleic Acids Res 1990; 18:5291.

Contact

Mailing Address

UNC Adams School of Dentistry Office of the Dean
CB 7450
Chapel Hill, N.C. 27599-7450

Email
janet_guthmiller@unc.edu
Administrative Assistant

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